As far as I can tell, it's basically the same game universe. So, I also don't see anything stupid or weird about allowing Astrid to have a relationship in 2 VN at once, united by a common story and lore...Astrid doesn't seem to have become a nun, taken a vow of celibacy.And her only limitation, in fact, is her confinement to a wheelchair, but if Veronica gets over Astrid illness quickly enough, I don't see any objective obstacle as to why the "white knight" Kane couldn't have a romance with her.
I'd like to believe that both devs are mature enough to realize that the audience isn't expecting them to do some childish nonsense like saying that "all female LI's for the male MC from TQA have to be chaste virgins who have never had a relationship before". So for me personally, the reason why Tess originally decided to give Astrid exclusively to Anais and her TQA has always looked pretty weird and hard to explain.