I have seen no such reports by briefly searching the official Ren'py forums, so I'm not too worried at the moment. The closest was an issue with antivirus two minor versions ago, but that was fixed. Still, I'm paying close attention to any reports.Belle
Just so that you know, from what I have seen in other games using the new version of Renpy, it does not play well with any Windows OS older than Windows 10.
Many of those game Devs had to quickly switch over to the older version of Renpy, because a lot of players still use older versions of Windows.
Windows XP is definitely not supported anymore, though.